Becareful about the overdose and toxic dangers of Vit. B6

An overdose of B6 (pyridoxine) can cause

  1. a temporary deadening of certain nerves such as the proprioceptory nerves; causing a feeling of disembodiment common with the loss of proprioception.
  2. This condition is reversible when supplementation is stopped.

Adverse effects_

  1. have only been documented from vitamin B6 supplements
  2. and never from food sources.

Although vitamin B6 is _

  1. a water-soluble vitamin
  2. and is excreted in the urine,

very high doses of pyridoxine over long periods of time may result in_

  1. painful neurological symptoms known as sensory neuropathy.
  2. Symptoms include pain and numbness of the extremities,
  3. and in severe cases difficulty walking.

Sensory neuropathy typically develops at_

  1. doses of pyridoxine in excess of 1,000 mg per day.
  2. However, there have been a few case reports of individuals who developed sensory neuropathies at doses of less than 500 mg daily over a period of months.
  3. None of the studies, in which an objective neurological examination was performed, found evidence of sensory nerve damage at intakes of pyridoxine below 200 mg/day.

In order to prevent sensory neuropathy in virtually all individuals, the Food and Nutrition Board of the Institute of Medicine set the tolerable upper intake level (UL) for pyridoxine at 100 mg/day for adults.

Because placebo-controlled studies have generally failed to show therapeutic benefits of high doses of pyridoxine, there is little reason to exceed the UL of 100 mg/day.

Source: Wikipedia Vitamin B6

So we must be careful about giving NEUROBION® TABLETS to our patients.

COMPOSITION:Each tablet contains

  Vitamin B1         100 mg
  Vitamin B6         200 mg
  Vitamin B12         200 micrograms

DOSAGE AND DIRECTIONS FOR USE:
NEUROBION tablets may be administered in a dosage of 1 daily.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS for Cyanocobalamin (B12). It should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord.
Cyanocobalamin is not a suitable form of Vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.

Vit B6 in Pregnancy_

Research studies have shown that taking extra vitamin B6 (also known as pyridoxine) helps relieve queasiness for some pregnant women, though no one knows exactly how it does this.

Pregnant women need only 1.9 milligrams (mg) of this vitamin a day to help make antibodies, red blood cells, and neurotransmitters and to meet the needs of their developing baby. Vitamin B6 is found in a wide variety of foods so you may satisfy this requirement by eating a nutritious diet. (Prenatal vitamins contain B6 as well.)

However, the dose commonly recommended for easing nausea and vomiting is much higher – 10 to 25 mg, three times a day.

As it is quite effective for giddiness, nausea and vomiting in pregnancy, some people and even few doctors are prescribing B6 in giddiness, nausea and vomiting in other diseases.

3 Responses to “Becareful about the overdose and toxic dangers of Vit. B6”

  1. E Ken Miller Says:

    I POSE A QUESTION REGARDING LONG TERM, MONTHS IF NOT YEARS, THAT i WAS ORDERED TO TAKE DAILY OVERDOSES OF COMMON SVC B 6 OFF THE SHELF(FOUND IN EVERY DRUG STORE) VITAMINS BY MY NEUROLOGIST FOR DIAGNOSED PURIFIAL NEUROPOTHY.
    AT ONE POINT, HE DISMISSED ME SAYING HE COULD NO LONGER TREAT ME EFFECTIVELY BUT, “KEEP ON YOUR B-6” ECHO’ED BY HIS PA AS THE DOOR SLAMMED SHUT. CURRENTLY I AM NOT BEING TREATED FOR ANY KIND OF NEUROPaTHY AND THE ORIGINAL SYMPTOMS ARE RETURNING WITH A BANG.
    I AM A 85 Y O MALE WITH ADDITIONAL HEALTH ISSUES COMMON TO MALES MY AGE AND HAVE BEEN UNTIL NOW THINKING OF PUTTING MYSELF BACK ON B-6 BUT WHAT YOU TELL ME HERE ABOUT IT MAKES ME WONDER IF I SHOULD?? MOST NEUROLOGIST IN THIS AREA BELONG TO THE SAME ASSOCIATION. SINCERELY. SORRY, i DON’T REMEMBER WHAT THE TOTAL DAILY DOSE OF B-6 WAS. ABOUT TRIPLE NORMAL, I THINK

  2. E Ken Miller Says:

    No comment, perhaps because the MAN, ME, DIDN’T HAVE THE ‘SUBMIT COMMENT’ BOX CHECKED??

  3. E Ken Miller Says:

    Right Ken, now let’s see what happens?

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s


%d bloggers like this: